Endometrial Microbiome and its Correlation to female infertility

The human body hosts a vast number of natural microorganisms, collectively known as the microbiome, which includes bacteria, viruses, and fungi. Humans have co-evolved with these trillions of microorganisms, adapting to physiological changes over time.

The balance of the microbiome varies across different organs in the body. Previously, it was believed that the uterus was sterile. However, advancements in medical technology and bacterial gene sequencing have revealed that the uterus has its unique microbiome, which can be categorized into two main types:

Lactobacillus dominant, accounting for over 90% of the endometrial microbiome

Lactobacillus non-dominant, accounting for less than 90% of the endometrial microbiome, with other bacterial species being more dominant

An imbalance in the microbiome, particularly a reduction in Lactobacillus dominance, can lead to a condition known as dysbiosis. Studies analyzing endometrial fluid or tissue samples have identified a significant correlation between the endometrial microbiome and female infertility. Research indicates that a Lactobacillus dominant microbiome enhances endometrial receptivity, thereby increasing the chances of pregnancy compared to women whose microbiomes are dominated by other bacterial species.

It has been shown that the administration of carefully selected probiotics, often following antibiotic treatment, can help restore a symbiotic microbiota. This restoration can potentially increase the success rates of pregnancy and improve outcomes in assisted reproductive technology (ART) treatments.

However, these studies lack consistency in clinical settings, particularly regarding the administration routes of Lactobacillus probiotics, which may be either oral or vaginal, as well as the dosage and duration of treatment.

 

Reference:

Jetanin Endometrial Microbiome and Its Correlation to Female Infertility
ArokaGO Providers Jetanin Hospital